LOCUS NT_030059 8714 bp DNA linear CON 17-OCT-2003 DEFINITION Homo sapiens chromosome 10 genomic contig. ACCESSION NT_030059 REGION: 34547341..34556054 VERSION NT_030059.11 GI:37550928 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 8714) AUTHORS International Human Genome Sequencing Consortium. TITLE The DNA sequence of Homo sapiens JOURNAL Unpublished (2003) COMMENT GENOME ANNOTATION REFSEQ: Features on this sequence have been produced for build 34 of the NCBI's genome annotation [see documentation]. On Oct 7, 2003 this sequence version replaced gi:29800185. The DNA sequence is part of the second release of the finished human reference genome. It was assembled from individual clone sequences by the Human Genome Sequencing Consortium in consultation with NCBI staff. COMPLETENESS: not full length. FEATURES Location/Qualifiers source 1..8714 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="10" source <1..>8714 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="RP11-86E10" /note="Accession AL355543 sequenced by The Sanger Centre" variation 81 /allele="A" /allele="G" /db_xref="dbSNP:2773469" variation 521 /allele="T" /allele="C" /db_xref="dbSNP:4917674" variation 657 /allele="G" /allele="A" /db_xref="dbSNP:7894700" variation 663 /allele="T" /allele="C" /db_xref="dbSNP:4917675" variation 2439 /allele="C" /allele="T" /db_xref="dbSNP:2429511" variation 2598 /allele="C" /allele="T" /db_xref="dbSNP:2532824" variation 2781 /allele="G" /allele="T" /db_xref="dbSNP:2050395" variation 4835 /allele="A" /allele="C" /db_xref="dbSNP:238743" gene 5001..6714 /gene="ADRB1" /note="Derived by automated computational analysis using gene prediction method: BestRefseq. Supporting evidence includes similarity to: 1 mRNA" /db_xref="GeneID:153" /db_xref="LocusID:153" /db_xref="MIM:109630" mRNA 5001..6714 /gene="ADRB1" /product="adrenergic, beta-1-, receptor" /note="unclassified transcription discrepancy; Derived by automated computational analysis using gene prediction method: BestRefseq. Supporting evidence includes similarity to: 1 mRNA" /transcript_id="NM_000684.1" /db_xref="GI:4557264" /db_xref="GeneID:153" /db_xref="LocusID:153" /db_xref="MIM:109630" CDS 5078..6511 /gene="ADRB1" /note="go_component: integral to plasma membrane [goid 0005887] [evidence TAS] [pmid 10212248]; go_component: plasma membrane [goid 0005886] [evidence E] [pmid 10212248]; go_function: beta1-adrenergic receptor activity [goid 0004940] [evidence TAS] [pmid 10212248]; go_function: beta-adrenergic receptor activity [goid 0004939] [evidence E]; go_function: rhodopsin-like receptor activity [goid 0001584] [evidence IEA]; go_process: adenylate cyclase activation [goid 0007190] [evidence TAS] [pmid 10212248]; go_process: G-protein coupled receptor protein signaling pathway [goid 0007186] [evidence IEA]" /codon_start=1 /product="beta-1-adrenergic receptor" /protein_id="NP_000675.1" /db_xref="GI:4557265" /db_xref="GeneID:153" /db_xref="LocusID:153" /db_xref="MIM:109630" variation 5222 /gene="ADRB1" /allele="G" /allele="A" /db_xref="dbSNP:1801252" variation 5392 /gene="ADRB1" /allele="T" /allele="G" /db_xref="dbSNP:7921133" variation 5833 /gene="ADRB1" /allele="A" /allele="G" /db_xref="dbSNP:238742" variation 5881 /gene="ADRB1" /allele="C" /allele="G" /db_xref="dbSNP:2773468" variation 6029 /gene="ADRB1" /allele="A" /allele="C" /db_xref="dbSNP:238741" variation 6048 /gene="ADRB1" /allele="A" /allele="G" /db_xref="dbSNP:622397" variation 6104 /gene="ADRB1" /allele="A" /allele="G" /db_xref="dbSNP:180897" variation 6133 /gene="ADRB1" /allele="G" /allele="T" /db_xref="dbSNP:189429" variation 6242 /gene="ADRB1" /allele="G" /allele="C" /db_xref="dbSNP:1801253" variation 6276 /gene="ADRB1" /allele="G" /allele="T" /db_xref="dbSNP:171170" variation 6385 /gene="ADRB1" /allele="C" /allele="T" /db_xref="dbSNP:365722" variation 6457 /gene="ADRB1" /allele="A" /allele="C" /db_xref="dbSNP:238740" variation 6566 /gene="ADRB1" /allele="C" /allele="T" /db_xref="dbSNP:171169" STS 6571..6673 /gene="ADRB1" /standard_name="GDB:193846" /db_xref="UniSTS:155762" variation 6575 /gene="ADRB1" /allele="A" /allele="C" /db_xref="dbSNP:238739" STS 6587..6711 /gene="ADRB1" /standard_name="RH68963" /db_xref="UniSTS:13016" variation 6989 /allele="T" /allele="G" /db_xref="dbSNP:1047284" STS 7140..7401 /standard_name="STS-U29690" /db_xref="UniSTS:13348" variation 7209 /allele="T" /allele="G" /db_xref="dbSNP:3177559" variation 7417 /allele="A" /allele="C" /db_xref="dbSNP:2210096" variation 7418..7419 /allele="C" /allele="-" /db_xref="dbSNP:3841344" variation 8068 /allele="T" /allele="C" /db_xref="dbSNP:3813719" variation 8202 /allele="T" /allele="C" /db_xref="dbSNP:3813720" variation 8257 /allele="G" /allele="A" /db_xref="dbSNP:3813721" repeat_region 422..631 /note="AluJo repeat: matches 97..312 of consensus" misc_feature 1972..2456 /note="match: GSS: Em:AQ403644" repeat_region 2461..2762 /note="AluSq repeat: matches 1..303 of consensus" repeat_region 3258..3289 /note="16 copies 2 mer tt 87% conserved" misc_feature 4270..6654 /note="CpG island" /evidence=not_experimental repeat_region 4322..4525 /note="102 copies 2 mer gg 60% conserved" repeat_region 4367..4486 /note="4 copies 30 mer 88% conserved" repeat_region 4378..4491 /note="19 copies 6 mer gggagc 68% conserved" repeat_region 4841..4906 /note="22 copies 3 mer cgg 80% conserved" repeat_region 4843..4902 /note="10 copies 6 mer gcggca 81% conserved" repeat_region 5885..5976 /note="46 copies 2 mer cc 66% conserved" repeat_region 5886..5981 /note="16 copies 6 mer cgcccg 71% conserved" repeat_region 6705..6824 /note="4 copies 30 mer 70% conserved" repeat_region 6709..6772 /note="32 copies 2 mer tt 84% conserved" repeat_region 8143..8166 /note="12 copies 2 mer aa 100% conserved" ORIGIN 1 atttcaaata gcttcaggct attatcagcc tcaaggcaca ttttgctaac agatttcgta 61 cacttcttgg ggttttatta agaaattccc ccacatatcc cttggcgtat cttccagcag 121 ttgtccagtt aggctactca cttttatttt taactcattt tctagtaaag tcaactcaag 181 aatgtaaatg tctttgccag gctcatggct tgcaaccttg gatgggttag atgcctattc 241 atcactgctc tgcagactaa tttgatatac aacttgaaac cacattcaag tcatcagcaa 301 ctctcctggg gcagaaatgg ctggatatat agattcggta tcataaataa tggctaaaga 361 aaaagactct tcacctgggt catttatgaa gaataggtag tacttttttc ttttcttttc 421 ttttcttttc ttttcttttt tttttttttt tgagttaggg tctcactctg tcacccaggc 481 tggagtgcag tggcacaacc acatttcact gcagcctcaa ctcctgggct caagtgatcc 541 tcctgactca gcctcccaaa gtgttgggat tacaggcagg agccactgag cctggccagg 601 tagtattttt tatggacgtg gacttgcatg tctcctttgg aaaatctctt acctatgtct 661 cgttttattt actacgaata ggtatgatat acatttatct catgagccta ccttgctttt 721 gtaaagtatt ttgaaatgtt tatgtgaaaa tgttgaatag gtggtaagaa tatggattat 781 tgctgtaaat tataagcaag agtgaagatt gtaactacta aaacactcaa ttatgtctca 841 agtgtataaa aatgagaata ttttaataaa ttaaatatca tatatttatg aatcaaagct 901 aaatgttcat taatatcaag taaatatcag taaacatggg agatataaaa atgtatgaga 961 caattctggc tctcagtgag cttacaatct ataagagaag aaaaggggaa aatataaaaa 1021 ttaaataaca acataagaag tatcaaaagg caacctattg taaattgcca cctgaaatga 1081 aattggcaga gtcactacta taggtcagag gaaggagaga tcattttcag aagcagtggg 1141 cagagaagat aaagagtcca gccacatctc caaggctgaa ttcgctggga agcaggagga 1201 ggttttggtg gagggaaccc agtgagaaag tatagatgta caaaaggaag gagtatggat 1261 ccccaaaagg aaaaagaata cagaaatgca agttatggtg ataaggagag ttctaatatg 1321 aaatagggct ggaaaggcca tttagaattg gaccggggag aactgtgaat gttaaattga 1381 agaggtaagg ttgctgaaca gaaaagcatc ttggtcaaag cagcattttg gaaatactcc 1441 tttggttatg atatgccaga ttaaatggag cagggaggac cagagacagg gagatcaaat 1501 agaacccatg gcaagtcccg gtgtggggtg aaggtggggg gatgggaaag gaagaagttg 1561 agataggaac tctgtggaag aagtgcacga cctctcaagt gtgctgatca gccctcattg 1621 ttggagcttt ctgtcatttt ccaaagcatt gtgaaatata tgggttttta gaactgactc 1681 tctttaacag ttgccaagtg aagaatgaag aaatgaagga gttttattta acttacaata 1741 tccgatacct gtaaaagttg atacgttgaa ccttttcttc ttgatcttgt atccttacct 1801 aagaataaaa agtgttaggc taaaaaaaaa gttaaaaaaa aaaaacacca atcataaaat 1861 gtaggaatta aaggagttct gagaacattt tatttttatt agacaaccaa ctctagttga 1921 acatgtacta ttccaaactc ttctgtcagt aaaattgaag gaaatccccc agaattcctg 1981 agatccctgt actggtactc ctgctagaat aaccttctgg tttcgagggt ttataattta 2041 atgtattata cagaaattcg gagaaacttg atgtatctct gaatgagcag agaaaaaaag 2101 tttcaggaaa gttttccaac aattccaatg tcacgatgtg tttatatata taatgatgat 2161 acggcaaagt tactggcaat ctggcttctg ccctgaacct ctacgaccaa gttctggcct 2221 tatcgcacac agaaaagcaa tgccttccac ccttcggggg catttaaggt tgacacactc 2281 tattccggta acaccacttg acagaaagat ggcaaggaaa agcctcttcc ccacattccc 2341 tatgcctcac cctgcagctc agcactcaga actcctttcc tgggcagcgt caatttcaac 2401 ttcttccaat cccttggcta ttttgagact gccccttgtg ggtccagaag gaagccagga 2461 ggccggggac agtggctcat gcctctaatc ccagcacttt gggaggccaa ggtgggtgga 2521 tcacctgagg tcaggagttc gagaccagcc tgaccaacat ggtaaaacgc catctccact 2581 aaaaatacaa aattagccgt gtgtggcggc acacgcctgt aatcccagct acttgacagg 2641 ctgaggcagg agaatcactt gaacccggga ggcagaggtt gcagtgggcc aagatcacgc 2701 cactgaactc cagcctgggc aacaaaagtg aaactctgtc tcaaaaaaat aaaaagaaag 2761 aagccaggag tctcaggctt tcagtgactt ggataacttg gggtgtagtc tccttcctcc 2821 cctttctaac gcctcttgtt tcctggccac tcctcctcaa cctccccaag ttggaaaatc 2881 agctgataaa tcatgggcag ggggtgaata aacaaatcac tccccagttt taacatactg 2941 atgctgaggt ttgggcctaa agcaaattca tatgtttgca tttatgtaag agaaagtggt 3001 taaaactgct tgattttata taaacttgaa aaacattact ttttgctttt gacctggaca 3061 gctgtggaag tcggtctctc cttgcaaggt aaggatatga gcttggtcat attgatgacc 3121 atcaacgaac atgatgttcg ttacgggcgc tgttcttatt ccaatgctag aaggacctgt 3181 gagcattata taacattttc atgcaccctt acataaacaa ttagaagctg tttactcctc 3241 aaggactcaa ttagagattt ttttaatttt tttatttttt tttttatttc aggcctgagc 3301 tgaggacact acaggagcca aattagagaa ggggcttgca gtcctgccat attgcatatt 3361 catggctttc ttgtcccctc acccccagta taatcctttt tgccaggtta acaactcact 3421 aatttcaaag caattcattt gccaactcaa aaaaaaaaaa aaaaaaaacc acagatacaa 3481 ctttaaatgc ttttggattt taatcctctg gagtatttat atgttttctt gtctcatccc 3541 ttcaaaacta atctcagagt tttgagaatc tgggaacttg ggcaaaggag aaaacaagca 3601 cgcagaccaa ggaatctgaa atcgcagttc attacgtcag cataaactga cagtaccttt 3661 ttgtttgtat tgacccagct caaattataa aatcacatga gtaataaaac acaaaataca 3721 ggtgttatca ttgaaaagtc taaaatgtaa ttaaacgcgt tttttccccc tcgcggtggt 3781 atcgtttact ctgtatctca acgtttctgt ctccctaagc ctctcctttc atatcatgag 3841 catacatttt tgcatcatgc tcacacgttc attagctagg actgaggagt gtgtacgatt 3901 ccaaagggcc ctcagcgtta gctgttagat gcacaaacct tcgcttcctt tccacatcta 3961 ctgcactcga ggttcaacag aggatccttg caagaacagc gcccagagag cattcttgac 4021 agatgcgcgc ttggctccag caacccgctc tgctgggaag tttcttctaa ccactaacac 4081 ccacctccaa tcccccaagc tgtcacgacg catgctggct gggtcccgtc ttgacggggg 4141 aagggtttta cacacaccct gctaggctgc cccacatcac aaccaagctc gcagggcaaa 4201 ctcctccaag cctggcggac aagctgtccc aggcgctctg gcgcttcctg aacaccaagg 4261 tcccctcccc gctcaaggga gctagcgctc tgttccgcag agaaccccgg aactgcaggt 4321 cgaggggatg cggggggagc gggggcgcag gagggagccg agtgctggag gcaaacgggg 4381 cgcaggagcg ggtgcgggag gcaaacgggg cgcaggagcg ggtgcgggag gcaaacgggg 4441 cgcaggagtg ggtgcgggag cgagtggggg ctgagggagg ggacggggcc ccggggggag 4501 ccaggcgcgg aagggggcgc gggggaacag ggaccaggaa ccagcgggcg caggaagggg 4561 tgcgtccgca ggaacccgcg ggcgcacggg aggcactagc tacgcgatca gctcgggact 4621 ctcaggagcc gctcaattgc caacgggagg ggggtgcggg gagttggagg tgggggtgca 4681 gaccagacgg gggcgtgcct ttgcccggat tggctgcagg agcctgacgc gaggccccgg 4741 gggttggctt ggggagtggg agcggggtgg ggtgggtgct gggtgccgga gctgcgggcc 4801 cggcgcgctc agaaacatgc tgaagtcccg gcggctcttc cagcagcggc agcggctcca 4861 gcagcagcgg cggcggcggc ggcggcggca gcggcagcga cagcgctcgg ctcctgcggg 4921 aaaggcgccc ggcgcccatg cctccggccc cgcgccgcgg ctgccctgac ccggccgcga 4981 cctccctctg cgcaccacgc cgcccgggct tctggggtgt tccccaacca cggcccagcc 5041 ctgccacacc ccccgccccc ggcctccgca gctcggcatg ggcgcggggg tgctcgtcct 5101 gggcgcctcc gagcccggta acctgtcgtc ggccgcaccg ctccccgacg gcgcggccac 5161 cgcggcgcgg ctgctggtgc ccgcgtcgcc gcccgcctcg ttgctgcctc ccgccagcga 5221 aagccccgag ccgctgtctc agcagtggac agcgggcatg ggtctgctga tggcgctcat 5281 cgtgctgctc atcgtggcgg gcaatgtgct ggtgatcgtg gccatcgcca agacgccgcg 5341 gctgcagacg ctcaccaacc tcttcatcat gtccctggcc agcgccgacc tggtcatggg 5401 gctgctggtg gtgccgttcg gggccaccat cgtggtgtgg ggccgctggg agtacggctc 5461 cttcttctgc gagctgtgga cctcagtgga cgtgctgtgc gtgacggcca gcatcgagac 5521 cctgtgtgtc attgccctgg accgctacct cgccatcacc tcgcccttcc gctaccagag 5581 cctgctgacg cgcgcgcggg cgcggggcct cgtgtgcacc gtgtgggcca tctcggccct 5641 ggtgtccttc ctgcccatcc tcatgcactg gtggcgggcg gagagcgacg aggcgcgccg 5701 ctgctacaac gaccccaagt gctgcgactt cgtcaccaac cgggcctacg ccatcgcctc 5761 gtccgtagtc tccttctacg tgcccctgtg catcatggcc ttcgtgtacc tgcgggtgtt 5821 ccgcgaggcc cagaagcagg tgaagaagat cgacagctgc gagcgccgtt tcctcggcgg 5881 cccagcgcgg ccgccctcgc cctcgccctc gcccgtcccc gcgcccgcgc cgccgcccgg 5941 acccccgcgc cccgccgccg ccgccgccac cgccccgctg gccaacgggc gtgcgggtaa 6001 gcggcggccc tcgcgcctcg tggccctgcg cgagcagaag gcgctcaaga cgctgggcat 6061 catcatgggc gtcttcacgc tctgctggct gcccttcttc ctggccaacg tggtgaaggc 6121 cttccaccgc gagctggtgc ccgaccgcct cttcgtcttc ttcaactggc tgggctacgc 6181 caactcggcc ttcaacccca tcatctactg ccgcagcccc gacttccgca aggccttcca 6241 gggactgctc tgctgcgcgc gcagggctgc ccgccggcgc cacgcgaccc acggagaccg 6301 gccgcgcgcc tcgggctgtc tggcccggcc cggacccccg ccatcgcccg gggccgcctc 6361 ggacgacgac gacgacgatg tcgtcggggc cacgccgccc gcgcgcctgc tggagccctg 6421 ggccggctgc aacggcgggg cggcggcgga cagcgactcg agcctggacg agccgtgccg 6481 ccccggcttc gcctcggaat ccaaggtgta gggcccggcg cggggcgcgg actccgggca 6541 cggcttccca ggggaacgag gagatctgtg tttacttaag accgatagca ggtgaactcg 6601 aagcccacaa tcctcgtctg aatcatccga ggcaaagaga aaagccacgg accgttgcac 6661 aaaaaggaaa gtttgggaag ggatgggaga gtggcttgct gatgttcctt gttgtttttt 6721 ttttcttttc ttttctttct tcttcttttt tttttttttt tttttttctg tttgtggtcc 6781 ggccttcttt tgtgtgtgcg tgtgatgcat ctttagattt ttttccccca ccaggtggtt 6841 tttgacactc tctgagagga ccggagtgga agatgggtgg gttaggggaa gggagaagca 6901 ttaggagggg attaaaatcg atcatcgtgg ctcccatccc tttcccggga acaggaacac 6961 actaccagcc agagagagga gaatgacagt ttgtcaagac atatttcctt ttgctttcca 7021 gagaaatttc attttaattt ctaagtaatg atttctgctg ttatgaaagc aaagagaaag 7081 gatggaggca aaataaaaaa aaatcacgtt tcaagaaatg ttaagctctt cttggaacaa 7141 gccccacctt gctttccttg tgtagggcaa acccgctgtc ccccgcgcgc ctgggtggtc 7201 aggctgaggg atttctacct cacactgtgc atttgcacag cagatagaaa gacttgttta 7261 tattaaacag cttatttatg tatcaatatt agttggaagg accaggcgca gagcctctct 7321 ctgtgacatg tgactctgtc aattgaagac aggacattaa aagagagcga gagagagaaa 7381 cagttcagat tactgcacat gtggataaaa acaaaaacaa aaaaaaggag tggttcaaaa 7441 tgccattttt gcacagtgtt aggaattaca aaatccacag aagatgttac ttgcacaaaa 7501 agaaattaaa tattttttaa agggagaggg gctgggcaga tcttaaataa aattcaaact 7561 ctacttctgt tgtctagtat gttattgagc taatgattca ttgggaaaat acctttttat 7621 actcctttat catggtactg taactgtatc catattataa atataattat cttaaggatt 7681 ttttattttt ttttatgtcc aagtgcccac gtgaatttgc tggtgaaagt tagcacttgt 7741 gtgtaaattc tacttcctct tgtgtgtttt accaagtatt tatactctgg tgcaactaac 7801 tactgtgtga ggaattggtc catgtgcaat aaataccaat gaagcacaat caagattatg 7861 tactgtgtgt ctgtaaaggg tcagtgacaa tgaaaaagac agcttgtttt gttcaaaata 7921 tagactggat ttcccataga gctcttttaa taggtttcca tgactcaata acatagcaaa 7981 atgcctccag acctaaataa ggtgtttacc tactgagagc tacagattta ccctacattt 8041 tcacagccgg attcaaggtg ttctagacta cttgtaggca ctttcaagat cccatctgct 8101 gcacttgact gaagaagtga cctttgtgat tgcgtagctc ctaaaaaaaa aaaaaaaaaa 8161 aaaaaagtga cgcggtcatt taactcagct gcaacttttc acggaaatgc aggaaagact 8221 aactcattga atgatcagtt gcctacttgg aatgcaataa gtggcttcca cagcttattt 8281 ttgttttcca atagaaaatc acagcctgcg gatgatcagt gtgtgcagat ttctccagag 8341 gctgtttaga atgaaaaatg ctttcatggt taagcaaaaa tgtataaaag ggcttctgaa 8401 gtaaattttt ttctcttatg tagttaaata gatcattttg ccagaagttc tgggtggaca 8461 gatcataggt aaaagcaagt gtgaaaggat ttaagtttcc aacaaaatta cagcacccaa 8521 aggatggggt atttttcata aagttatttc ctaaaggaag ggatagtgca attctgtcct 8581 gagattaatt ttacattctc caaaatacat ttaaagttct tactatattt ttaaataagc 8641 tttttatttc atgaccatac agtaaagaaa ccaaagtaaa gaatattaac ttctggctta 8701 tgctgcactt taaa //