LOCUS       NT_006081               2819 bp    DNA     linear   CON 17-OCT-2003
DEFINITION  Homo sapiens chromosome 4 genomic contig.
ACCESSION   NT_006081 REGION: 1153972..1156790
VERSION     NT_006081.16  GI:37540627
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2819)
  AUTHORS   International Human Genome Sequencing Consortium.
  TITLE     The DNA sequence of Homo sapiens
  JOURNAL   Unpublished (2003)
COMMENT     GENOME ANNOTATION REFSEQ:  Features on this sequence have been
            produced for build 34 of the NCBI's genome annotation [see
            documentation].
            On Oct 7, 2003 this sequence version replaced gi:29791395.
            The DNA sequence is part of the second release of the finished
            human reference genome. It was assembled from individual clone
            sequences by the Human Genome Sequencing Consortium in consultation
            with NCBI staff.
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     source          1..2819
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     source          <1..>2819
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="XXfos-85085A9"
                     /note="Accession AC141928 sequenced by Washington
                     University, Genome Sequencing Center"
     gene            1..2819
                     /gene="ADRA2C"
                     /note="Derived by automated computational analysis using
                     gene prediction method: BestRefseq. Supporting evidence
                     includes similarity to: 1 mRNA"
                     /db_xref="GeneID:152"
                     /db_xref="LocusID:152"
                     /db_xref="MIM:104250"
     mRNA            1..2819
                     /gene="ADRA2C"
                     /product="adrenergic, alpha-2C-, receptor"
                     /note="unclassified transcription discrepancy; Derived by
                     automated computational analysis using gene prediction
                     method: BestRefseq. Supporting evidence includes
                     similarity to: 1 mRNA"
                     /transcript_id="NM_000683.2"
                     /db_xref="GI:15718672"
                     /db_xref="GeneID:152"
                     /db_xref="LocusID:152"
                     /db_xref="MIM:104250"
     CDS             905..2290
                     /gene="ADRA2C"
                     /note="alpha2-AR-C4;
                     go_component: endosome [goid 0005768] [evidence TAS] [pmid
                     10196213];
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence TAS] [pmid 9371698];
                     go_function: alpha2-adrenergic receptor activity [goid
                     0004938] [evidence TAS] [pmid 9371698];
                     go_function: rhodopsin-like receptor activity [goid
                     0001584] [evidence IEA];
                     go_function: adrenoceptor activity [goid 0004935]
                     [evidence IEA];
                     go_process: activation of MAPK [goid 0000187] [evidence
                     TAS] [pmid 10196213];
                     go_process: G-protein coupled receptor protein signaling
                     pathway [goid 0007186] [evidence TAS] [pmid 9371698];
                     go_process: behavior [goid 0007610] [evidence NR];
                     go_process: cell-cell signaling [goid 0007267] [evidence
                     TAS] [pmid 9371698]"
                     /codon_start=1
                     /exception="unclassified translation discrepancy"
                     /product="alpha-2C-adrenergic receptor"
                     /protein_id="NP_000674.1"
                     /db_xref="GI:4501967"
                     /db_xref="GeneID:152"
                     /db_xref="LocusID:152"
                     /db_xref="MIM:104250"
     variation       2032
                     /gene="ADRA2C"
                     /allele="C"
                     /allele="G"
                     /db_xref="dbSNP:7435505"
     variation       2071
                     /gene="ADRA2C"
                     /allele="C"
                     /allele="T"
                     /db_xref="dbSNP:7434630"
     variation       2106
                     /gene="ADRA2C"
                     /allele="T"
                     /allele="G"
                     /db_xref="dbSNP:1133450"
     STS             2111..2231
                     /gene="ADRA2C"
                     /standard_name="STS-J03853"
                     /db_xref="UniSTS:13513"
     variation       2241
                     /gene="ADRA2C"
                     /allele="G"
                     /allele="C"
                     /db_xref="dbSNP:1133452"
     variation       2248
                     /gene="ADRA2C"
                     /allele="T"
                     /allele="C"
                     /db_xref="dbSNP:1133453"
     STS             2601..2735
                     /gene="ADRA2C"
                     /standard_name="D4S3282"
                     /db_xref="UniSTS:75023"
     variation       2640
                     /gene="ADRA2C"
                     /allele="C"
                     /allele="G"
                     /db_xref="dbSNP:7434444"
     misc_feature    <1..2360
                     /note="CpG_island (%GC=75.4, o/e=0.90, #CpGs=392)"
     repeat_region   18..169
                     /rpt_family="GC_rich"
     repeat_region   230..251
                     /rpt_family="(CGG)n"
     repeat_region   295..360
                     /rpt_family="GC_rich"
     repeat_region   385..612
                     /rpt_family="GC_rich"
     repeat_region   727..801
                     /rpt_family="GC_rich"
     repeat_region   915..953
                     /rpt_family="(CGG)n"
     repeat_region   1812..1886
                     /rpt_family="G-rich"
ORIGIN      
        1 ctgcaggcgg ccctggaggg ggcgccctcg ccgagcgcgc gccccgcgcc gccgccccgg
       61 actcctcccc ggcgccgcgc gggcaggttc gaccaggcgg ccgcgggctc cggttcccgg
      121 ccagctcccc agggcccgcg gcccgccccg ccccgcgcgc ccgccccgct gcgcaactcg
      181 acccaagttg gaagccgatc gcaggcggcc gcactcgcgc ccagcgcagg gcggcggcgg
      241 cggcggcggc gcagctccgg cgagcgaggc ggcggccgca cggccaagcg tggaccgcgg
      301 ggggcgcccg cgcccgggag cagccggagg actcgcggcg gcgccggcgc cccgcccggg
      361 aaagtaaagt tggagacgga gggagcgcgc gggcgcgggg gcccggagga gcggcggccg
      421 gcgccccggc gcgccgagcc ctagccggcc ggatgggagg cggagcgccc gggccgccgc
      481 cgcctgtcgc ctgcgccccg gctgggctcc gggaccgcgg ggccgctcag gcacgcccgc
      541 tcgggcgccg cgtcgccgtg ggctcgacgc cggggcgctc cccgtgagcc gggccgaggg
      601 cggggccgcg cgaggacccc gggacctgcc cccctccccc cgcagccgcg tcgccgctcg
      661 ctccgggcgc ctcctgctct gcacttacac gctcggcagc tgcggggagc ccggcagcca
      721 cgctctccgg cgcgccgccc gcggagccac cacggccgag ggccggctgc tgggcgccgc
      781 ggtccccggc gggcgcgccc gagcagcagg cggcgatgcg ggcgccgacc ccggctgggg
      841 ggcgcccgag ctgccgcggc tgcgccccgg ctccaggagg gacggcgtag ctcgcgggag
      901 gaccatggcg tccccggcgc tggcggcggc gctggcggtg gcggcagcgg cgggccccaa
      961 tgcgagcggc gcgggcgaga ggggcagcgg cggggttgcc aatgcctcgg gggcttcctg
     1021 ggggccgccg cgcggccagt actcggcggg cgcggtggca gggctggctg ccgtggtggg
     1081 cttcctcatc gtcttcaccg tggtgggcaa cgtgctggtg gtgatcgccg tgctgaccag
     1141 ccgggcgctg cgcgcgccac agaacctctt cctggtgtcg ctggcctcgg ccgacatcct
     1201 ggtggccacg ctggtcatgc ccttctcgtt ggccaacgag ctcatggcct actggtactt
     1261 cgggcaggtg tggtgcggcg tgtacctggc gctcgatgtg ctgttttgca cctcgtcgat
     1321 cgtgcatctg tgtgccatca gcctggaccg ctactggtcg gtgacgcagg ccgtcgagta
     1381 caacctgaag cgcacaccac gccgcgtcaa ggccaccatc gtggccgtgt ggctcatctc
     1441 ggccgtcatc tccttcccgc cgctggtctc gctctaccgc cagcccgacg gcgccgccta
     1501 cccgcagtgc ggcctcaacg acgagacctg gtacatcctg tcctcctgca tcggctcctt
     1561 cttcgcgccc tgcctcatca tgggcctggt ctacgcgcgc atctaccgag tggccaagct
     1621 gcgcacgcgc acgctcagcg agaagcgcgc ccccgtgggc cccgacggtg cgtccccgac
     1681 taccgaaaac gggctgggcg cggcggcagg cgcaggcgag aacgggcact gcgcgccccc
     1741 gcccgccgac gtggagccgg acgagagcag cgcagcggcc gagaggcggc ggcgccgggg
     1801 cgcgttgcgg cggggcgggc ggcggcgagc gggcgcggag gggggcgcgg gcggtgcgga
     1861 cgggcagggg gcggggccgg gggcggctga gtcgggggcg ctgaccgcct ccaggtcccc
     1921 ggggcccggt ggccgcctgt cgcgcgccag ctcgcgctcc gtcgagttct tcctgtcgcg
     1981 ccggcgccgg gcgcgcagca gcgtgtgccg ccgcaaggtg gcccaggcgc gcgagaagcg
     2041 cttcaccttt gtgctggctg tggtcatggg cgtgttcgtg ctctgctggt tccccttctt
     2101 cttcagctac agcctgtacg gcatctgccg cgaggcctgc caggtgcccg gcccgctctt
     2161 caagttcttc ttctggatcg gctactgcaa cagctcgctc aacccggtca tctacacggt
     2221 cttcaaccag gatttccggc gatcctttaa gcacatcctc ttccgacgga ggagaagggg
     2281 cttcaggcag tgactcgcac ccgtctggga atcctggaca gctccgcgct cggggctggg
     2341 cagaaggggc ggcccggacg ggggagcttt cccagagacc cggggatgga ttggcctcca
     2401 gggcgcaggg gagggtgcgg cagggcagga gcttggcaga gagatagccg ggctccaggg
     2461 agtggggagg agagaggggg agaccccttt gccttccccc ctcagcaagg ggctgcttct
     2521 ggggctccct gcctggatcc agctctggga gccctgccga ggtgtggctg tgaggtcagg
     2581 gttttagaga gcagtggcag aggtagcccc ctaaatgggc aagcaaggag ccccccaaag
     2641 acactaccac tccccatccc cgtctgacca agggctgact tctccaggac ctagtcgggg
     2701 ggtggctgcc agggggcaag gagaaagcac cgacaatctt tgattactga aagtatttaa
     2761 atgtttgcca aaaacaacag ccaaaacaac caaactattt tctaaataaa cctttgtaa
//