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Cell Proliferation:

AKT1; v-akt murine thymoma viral oncogene homolog 1, 14q32.32

AKT2; v-akt murine thymoma viral oncogene homolog 2, 19q13.1-q13.2

AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma), 1q43-q44

CDKN2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), 9p21

CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), 9p21

IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, 8p11.2

IL1B; interleukin 1, beta, 2q14

IL1R1; interleukin 1 receptor, type I, 2q12

IL2; interleukin 2, 4q26-q27

IL2RA; interleukin 2 receptor, alpha, 10p15-p14

IL2RG; interleukin 2 receptor, gamma (severe combined immunodeficiency), Xq13.1

IL6; interleukin 6 (interferon, beta 2), 7p21

IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor), 5q11

IRAK4; interleukin-1 receptor-associated kinase 4, 12q12

MAP3K7; mitogen-activated protein kinase kinase kinase 7, 6q16.1-q16.3

MAPK14; mitogen-activated protein kinase 14, 6p21.3-p21.2

MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor), 22q11.23

MLLT7; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7, Xq13.1

MYD88; myeloid differentiation primary response gene (88), 3p22

NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, 14q13

PDPK1; 3-phosphoinositide dependent protein kinase-1, 16p13.3

PIK3C2A; phosphoinositide-3-kinase, class 2, alpha polypeptide, 11p15.5-p14

PIK3C2B; phosphoinositide-3-kinase, class 2, beta polypeptide, 1q32

PIK3C2G; phosphoinositide-3-kinase, class 2, gamma polypeptide, 12p12

PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide, 3q26.3

PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide, 3q22.3

PIK3CD; phosphoinositide-3-kinase, catalytic, delta polypeptide, 1p36.2

PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide, 7q22.3

PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha), 5q13.1

PIK3R1OS; phosphoinositide-3-kinase, regulatory subunit 1, opposite strand, 5

PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta), 19q13.2-q13.4

PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma), 1p34.1

PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4, p150, 3q21.3

PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5, p101, 17p13.1

PPARA; peroxisome proliferative activated receptor, alpha, 22q12-q13.1

PPARBP; PPAR binding protein, 17q12-q21.1

PPARD; peroxisome proliferative activated receptor, delta, 6p21.2-p21.1

PPARG; peroxisome proliferative activated receptor, gamma, 3p25

PPARGC1A; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha, 4p15.1

PPARGC1B; peroxisome proliferative activated receptor, gamma, coactivator 1, beta, 5q32

PPRC1; peroxisome proliferative activated receptor, gamma, coactivator-related 1, 10q24.32

PROP1; prophet of Pit1, paired-like homeodomain transcription factor, 5q35.3

PTEN; phosphatase and tensin homolog (mutated in multiple advanced cancers 1), 10q23.3

RELA; v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian), 11q13

RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1, 6p25.2

RIPK2; receptor-interacting serine-threonine kinase 2, 8q21

RIPK3; receptor-interacting serine-threonine kinase 3, 14q11.2

RIPK4; receptor-interacting serine-threonine kinase 4, 21q22.3

RIPK5; receptor interacting protein kinase 5, 1q32.1

SHC1; SHC (Src homology 2 domain containing) transforming protein 1, 1q21

SHC2; SHC (Src homology 2 domain containing) transforming protein 2, 19p13.3

SHC3; src homology 2 domain containing transforming protein C3, 9q22.1-q22.2

SHCBP1; SHC SH2-domain binding protein 1, 16q11.2

SIRT1; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), 10q21.3

STAT3; signal transducer and activator of transcription 3 (acute-phase response factor), 17q21.31

TNFAIP1; tumor necrosis factor, alpha-induced protein 1 (endothelial), 17q22-q23

TNFAIP2; tumor necrosis factor, alpha-induced protein 2, 14q32

TNFAIP3; tumor necrosis factor, alpha-induced protein 3, 6q23

TNFAIP8; tumor necrosis factor, alpha-induced protein 8, 5q23.1

TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A, 12p13.2

TP53; tumor protein p53 (Li-Fraumeni syndrome), 17p13.1

TRADD; TNFRSF1A-associated via death domain, 16q22

TRAF1; TNF receptor-associated factor 1, 9q33-q34

TRAF2; TNF receptor-associated factor 2, 9q34

 

Cognitive Impairment:

APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), 11p15

APOE; apolipoprotein E, 19q13.2

APP; amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease), 21q21.2

PSEN1; presenilin 1 (Alzheimer disease 3), 14q24.3

PSEN2; presenilin 2 (Alzheimer disease 4), 1q31-q42

RGN; regucalcin (senescence marker protein-30), Xp11.3

 

Degenerative Processes:

BAX; BCL2-associated X protein, 19q13.3-q13.4

KL; klotho, 13q12

PARK2; Parkinson disease (autosomal recessive, juvenile) 2, parkin, 6q25.2-q27

UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase), 4p14

 

DNA Metabolism:

ATM; ataxia telangiectasia mutated (includes complementation groups A, C and D), 11q22-q23

BLM; Bloom syndrome, 15q26.1

ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D), 19q13.3

ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8, 5q12.1

GADD45A; growth arrest and DNA-damage-inducible, alpha, 1p31.2-p31.1

GADD45B; growth arrest and DNA-damage-inducible, beta, 19p13.3

GADD45G; growth arrest and DNA-damage-inducible, gamma, 9q22.1-q22.2

TOP1; topoisomerase (DNA) I, 20q12-q13.1

TOP2A; topoisomerase (DNA) II alpha 170kDa, 17q21-q22

TOP3A; topoisomerase (DNA) III alpha, 17p12-17p11.2

TOP3B; topoisomerase (DNA) III beta, 22q11.22

WRN; Werner syndrome, 8p12-p11.2

 

Heat Shock:

HSPA9B; heat shock 70kDa protein 9B (mortalin-2), 5q31.1

HSPCA; heat shock 90kDa protein 1, alpha, 14q32.33

 

Insulin Signaling / Metabolism:

FOXC2; forkhead box C2 (MFH-1, mesenchyme forkhead 1), 16q22-16q24

FOXD1; forkhead box D1, 5q12-q13

FOXO1A; forkhead box O1A (rhabdomyosarcoma), 13q14.1

FOXO3A; forkhead box O3A, 6q21

FOXO6; forkhead box protein O6, 1p34.1

FOXP1; forkhead box P1, 3p14.1

FOXP2; forkhead box P2, 7q31

FOXP4; forkhead box P4, 6p21.1

GHR; growth hormone receptor, 5p13-p12

GHRHR; growth hormone releasing hormone receptor, 7p14

IGF1; insulin-like growth factor 1 (somatomedin C), 12q22-q23

IGF1R; insulin-like growth factor 1 receptor, 15q26.3

IGF2; insulin-like growth factor 2 (somatomedin A), 11p15.5

IGF2R; insulin-like growth factor 2 receptor, 6q26

INS; insulin, 11p15.5

INSR; insulin receptor, 19p13.3-p13.2

INSRL; insulin receptor-like, 7p13-q22

INSRR; insulin receptor-related receptor, 1q21-q23

IRS1; insulin receptor substrate 1, 2q36

IRS2; insulin receptor substrate 2, 13q34

IRS3L; insulin receptor substrate 3-like, 7q22

IRS4; insulin receptor substrate 4, Xq22.3

MAPK1; mitogen-activated protein kinase 1, 22q11.2

MAPK3; mitogen-activated protein kinase 3, 16p12-p11.2

PBK; PDZ binding kinase, 8p21.2

PLK1; polo-like kinase 1 (Drosophila), 16p12.1

PLK2; polo-like kinase 2 (Drosophila), 5q12.1-q13.2

PLK3; polo-like kinase 3 (Drosophila), 1p34.1

POU1F1; POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), 3p11

RETN; resistin, 19p13.2

SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4, 17p13

SLC2A4RG; SLC2A4 regulator, 20q13.33

TNF; tumor necrosis factor (TNF superfamily, member 2), 6p21.3

 

mtDNA-encoded Proteins:

ATP6; mitochondrially encoded ATP synthase 6,  

ATP8; mitochondrially encoded ATP synthase 8,  

CO1; mitochondrially encoded cytochrome c oxidase I,  

CO2; mitochondrially encoded cytochrome c oxidase II,  

CO3; mitochondrially encoded cytochrome c oxidase III,  

ND1; mitochondrially encoded NADH dehydrogenase 1,  

ND2; mitochondrially encoded NADH dehydrogenase 2,  

ND3; mitochondrially encoded NADH dehydrogenase 3,  

ND4; mitochondrially encoded NADH dehydrogenase 4,  

ND4L; mitochondrially encoded NADH dehydrogenase 4L,  

ND5; mitochondrially encoded NADH dehydrogenase 5,  

ND6; mitochondrially encoded NADH dehydrogenase 6,  

 

Nuclear-encoded Mito-Proteins:

DGUOK; deoxyguanosine kinase, 2p13

ECGF1; endothelial cell growth factor 1 (platelet-derived), 22q13

ENDOG; endonuclease G, 9q34.1

OGG1; 8-oxoguanine DNA glycosylase, 3p26.2

PEO1; progressive external ophthalmoplegia 1, 10q23.3-24.3

POLG; polymerase (DNA directed), gamma, 15q25

POLG2; polymerase (DNA directed), gamma 2, accessory subunit, 17q

SLC25A4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4, 4q35

SSBP1; single-stranded DNA binding protein 1, 7q34

TFAM; transcription factor A, mitochondrial, 10q21

TK1; thymidine kinase 1, soluble, 17q23.2-q25.3

TK2; thymidine kinase 2, mitochondrial, 16q22-q23.1

TOP1MT; topoisomerase (DNA) I, mitochondrial, 8q24.3

UNG; uracil-DNA glycosylase, 12q23-q24.1

 

Stress and Inflammation / Thrombosis:

APC; adenomatosis polyposis coli, 5q21-q22

ASIP; agouti signaling protein, nonagouti homolog (mouse), 20q11.2-q12

CCL2; chemokine (C-C motif) ligand 2, 17q11.2-q21.1

CD14; CD14 antigen, 5q22-q32

CPB2; carboxypeptidase B2 (plasma, carboxypeptidase U), 13q14.11

CRP; C-reactive protein, pentraxin-related, 1q21-q23

F2; coagulation factor II (thrombin), 11p11-q12

F7; coagulation factor VII (serum prothrombin conversion accelerator), 13q34

F9; coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B), Xq27.1-q27.2

FGA; fibrinogen, A alpha polypeptide, 4q28

FGB; fibrinogen, B beta polypeptide, 4q28

FGG; fibrinogen, gamma polypeptide, 4q28

FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), 13q12

MSRA; methionine sulfoxide reductase A, 8p23.1

NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), 4q24

PLAT; plasminogen activator, tissue, 8p12

PLAU; plasminogen activator, urokinase, 10q24

PLAUR; plasminogen activator, urokinase receptor, 19q13

PLG; plasminogen, 6q26

PRAP1; proline-rich acidic protein 1, 10q26.3

PROC; protein C (inactivator of coagulation factors Va and VIIIa), 2q13-q14

SERPINA1; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, 14q32.1

SERPINE1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, 7q21.3-q22

SNCA; synuclein, alpha (non A4 component of amyloid precursor), 4q21

SOD1; superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)), 21q22.1

SOD2; superoxide dismutase 2, mitochondrial, 6q25.3

TAF6; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa, 7q22.1

THBD; thrombomodulin, 20p12-cen

TLR1; toll-like receptor 1, 4p14

TLR2; toll-like receptor 2, 4q32

TLR3; toll-like receptor 3, 4q35

TLR4; toll-like receptor 4, 9q32-q33

TLR5; toll-like receptor 5, 1q41-q42

TLR6; toll-like receptor 6, 4p14

VEGF; vascular endothelial growth factor, 6p12

VEGFB; vascular endothelial growth factor B, 11q13

VEGFC; vascular endothelial growth factor C, 4q34.1-q34.3

 

Telomere Metabolism:

TERC; telomerase RNA component, 3q26

TERT; telomerase reverse transcriptase, 5p15.33

 

Other Longevity Proteins:

MORF4; mortality factor 4, 4q33-q34.1

 

 

Others:

ABT1; activator of basal transcription 1, 6p22.1

GAPD; glyceraldehyde-3-phosphate dehydrogenase, 12p13

 

 

National Institute of Aging

Longevity Consortium


Longevity

Candidate Loci


Longevity Sites: | Longevity Consortium | SAGE KE | Senescence | Alliance for Aging Research |
Other: | Hypertension Candidate Loci | Hypertension Home Page | DNASYSTEM Home Page |


Select a locus from the List to the left

or Search for a locus by yourself.

The default List to the left shows Human loci,
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Click on the 'Mouse' button to the left
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Click on the 'Search' button to the left
to see ALL loci organized alphabetically,
with organism presented as 'Hs' for Human and 'Mm' for Mouse.

Latest update: 20 August, 2005

If you have comments or queries, please send email to Doug Smith